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In the hippocampus of human alcoholics, prolonged ethanol treatment reduces the number of muscarinic ligand binding sites present at autopsy suggesting a decrease in functional muscarinic receptors. Whether these changes are due to alcohol-induced brain damage or ethanol dependence and represent a reduced level of cholinergic function is unknown. The present studies tested the impact of ethanol...
The purpose of this study was to determine the effects of chronic ethanol ingestion on components of mid-latency auditory evoked potentials (MAEPs). Male Sprague-Dawley rats were administered 10% ethanol in drinking water for 10 months. MAEPs were obtained and compared to age-matched controls provided tap water. Data were obtained for varying frequencies (4, 8, 16, 24, and 32 kHz) and intensities...
The activities of enzymes participating in cellular protection against free radical reactions were measured in hepatic tissues from copper-adequate and copper-deficient rats fed fructose or starch-based diets. Half of the rats consumed 20% ethanol in their drinking water. The consumption of ethanol depressed growth rate, reduced hematocrit, and hepatic copper concentration. Feed efficiency was...
The effects of acute treatment with alcohol on prolactin (PRL) surge and immunohistochemical features of PRL cells and α-melanocyte-stimulating hormone (α-MSH) cells in lactating rats were investigated. In light microscopic observations, one could see numerous large, lightly immunoreactive PRL cells in the pars distalis of control lactating rats. These cells revealed well-developed Golgi zones, prominently...
Male rats were intubated with either 5, 2.5, or 0 g/kg alcohol. Animals in the latter two groups were pairfed to those in the 5 g/kg group. A fourth group of males was not treated and was fed ad lib. Males were bred once after 3 weeks of intubation and twice after 9 weeks of intubation. Females in the first two breedings were sacrificed prior to delivery, whereas females in the last breeding were...
Prenatal alcohol exposure delays the development of thermoregulation in newborn rats. Newborns generate heat by the sympathetic nervous system's activation of nonshivering thermogenesis in brown adipose tissue (BAT). In this study, the effects of prenatal alcohol exposure on the development of the β-adrenergic receptor system of BAT was investigated by assessing the number and pharmacological properties...
It has been reported that prolonged prothrombin time may be a result of the interaction of acetaldehyde (AcH) with clotting proteins to form alkylated inactive products. The current investigation focuses on the influence of l-cysteine (CysH), dl-homocysteine (HC),D -penicillamine,N -acetyl-l-cysteine (NAC), l-serine and l-alanine at 0.01 M concentrations, lactalbumin hydrolysate (2 mg/ml), and 1...
Since acute ethanol consumption and riboflavin deficiency each induces oxidative stress within tissues, we examined whether their combined effects compromise the major antioxidative system in liver, namely, reduced glutathione (GSH) metabolism. Four hours before sacrifice, half the riboflavin-deficient (RD) and riboflavin-sufficient (RS) rats were treated with ethanol (3 g/kg). Livers were excised...
Some of the multiple biological effects of stress include activation of a variety of neuroendocrine systems, resulting in enhanced secretion of many hormones, including corticosterone, as well as facilitation of drug-seeking behavior. Therefore, we have examined the potential relationship between voluntary alcohol consumption (VAC) and corticosterone output profile using: (1) selectively bred alcohol-preferring...
In two separate studies, the relationship between home-cage, two bottle ethanol/water consumption and both initial motor reactivity to a novel environment and amphetamine induced motor activity was determined in nonselected Wistar rats. In neither study was any correlation found. While home-cage ethanol consumption may not be an accurate measure of ethanol self-administration, the studies suggest...
Weight reduction and food restriction increase the self-administration of alcohol and other drugs of abuse, but the underlying physiological mechanisms have not been identified. Because weight reduction alters angiotensin (ANG) II activity, and ANG II is known to modulate alcohol intake, ANG II may play a role in the enhanced alcohol consumption of food-deprived weight-reduced rats and in the drop...
Chronic ethanol abuse has been shown to cause damage to skeletal muscle in animals and patients as reflected by elevated serum levels of cytosolic enzymes and histological examination. The present study investigated the hypothesis that elevated serum creatine kinase levels in ethanol-treated animals vs. sucrose control animals may result from increased enzyme release or efflux from muscle. Creatine...
One hundred percent of anesthetized rats administered 6.6 gm/kg of ethanol IP died within 10-35 min of alcohol injection; upon autopsy of the brain all demonstrated profound subarachnoid and intracranial bleeding, clear signs of hemorrhagic stroke. Pretreatment of rats with 4 μmol/min MgCl 2 , but not saline, via IV administration (for 30-45 min), prevented hemorrhagic stroke in all animals...
Recent epidemiologic data continue to support alcoholic beverage consumption as a cause of cancer of the mouth, pharynx, larynx, esophagus, and liver. The effect of a given alcohol intake on absolute risk of these cancers depends on the prevalence of other risk factors. Whether alcoholic beverage consumption is a cause of cancer of the breast or large bowel is unclear. Alcohol intake appears not...
Consumption of alcoholic beverages is an accepted social custom world-wide. This makes its involvement in events contributing to human cancer risk very important. Although it is neither tumorigenic nor genotoxic in animals, ethanol can potentiate the carcinogenic risk associated with certain environmentally present agents. The reasons for such a synergistic action are speculative, but among theories...
Deficiency of mitochondrial aldehyde dehydrogenase (ALDH2) has been previously reported in South American Indians. We therefore assayed five individuals from each of five South American Indian populations (Quechua, Karitiana, Ticuna, Surui, Guahiba), and two North American populations (Maya and Moskoke) for the presence of the Oriental ALDH 22 variant. These samples were also surveyed...
6-Hydroxydopamine (6-OHDA) was administered ICV to Wistar male rats. Lesioned animals displayed lower preference for ethanol (ETOH) than sham-operated rats. Among 6-OHDA lesioned rats only 9% became high-preferring whereas 20% of sham-operated animals became high-preferring ones. Both tropisetron (the antagonist of 5-HT 3 receptors) and 8-OHDPAT (the 5-HT 1A receptor agonist)...
Incubation of lysozyme with acetaldehyde (0.44 M) at room temperature for 2 h produces a 62% inhibition of enzymic activity. Because the active site cleft contains tryptophyls, asparagine, glutamine, and an arginine residue, and because acetaldehyde reacts with indoles, amides, and guanidines, it is suggested that these sites are likely ones for alkylation. The ε-amino groups of lysines on the surface...
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